Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 14/01/22 17:30 | 14/01/22 17:20 | FC Hansa Rostock | Hannover 96 | 0-1 | 2 - 4 points |
| 14/01/22 17:30 | 14/01/22 17:20 | Dynamo Dresden | Hamburger SV | 1-1 | 2 - 4 points |
| 15/01/22 12:30 | 15/01/22 12:20 | Werder Bremen | Fortuna Düsseldorf | 3-0 | 2 - 4 points |
| 15/01/22 12:30 | 15/01/22 12:20 | FC St. Pauli | Erzgebirge Aue | 2-2 | 2 - 4 points |
| 15/01/22 12:30 | 15/01/22 12:20 | 1. FC Nürnberg | SC Paderborn 07 | 1-2 | 2 - 4 points |
| 15/01/22 19:30 | 15/01/22 19:20 | SV Darmstadt 98 | Karlsruher SC | 2-2 | 2 - 4 points |
| 16/01/22 12:30 | 16/01/22 12:20 | FC Schalke 04 | Holstein Kiel | 1-1 | 2 - 4 points |
| 16/01/22 12:30 | 16/01/22 12:20 | 1. FC Heidenheim 1846 | FC Ingolstadt | 2-1 | 2 - 4 points |
| 16/01/22 12:30 | 16/01/22 12:20 | SV Sandhausen | Jahn Regensburg | 0-3 | 2 - 4 points |