Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 03/12/21 19:30 | 03/12/21 19:20 | 1. FC Union Berlin | RB Leipzig | 2-1 | 1 - 3 points |
| 04/12/21 14:30 | 04/12/21 14:20 | FSV Mainz 05 | VfL Wolfsburg | 3-0 | 1 - 3 points |
| 04/12/21 14:30 | 04/12/21 14:20 | 1899 Hoffenheim | Eintracht Frankfurt | 3-2 | 1 - 3 points |
| 04/12/21 14:30 | 04/12/21 14:20 | Bayer 04 Leverkusen | SpVgg Greuther Fürth | 7-1 | 1 - 3 points |
| 04/12/21 14:30 | 04/12/21 14:20 | Arminia Bielefeld | 1. FC Köln | 1-1 | 1 - 3 points |
| 04/12/21 14:30 | 04/12/21 14:20 | FC Augsburg | VfL Bochum | 2-3 | 1 - 3 points |
| 04/12/21 17:30 | 04/12/21 17:20 | Borussia Dortmund | FC Bayern Munich | 2-3 | 1 - 3 points |
| 05/12/21 14:30 | 05/12/21 14:20 | VfB Stuttgart | Hertha BSC | 2-2 | 1 - 3 points |
| 05/12/21 16:30 | 05/12/21 16:20 | Bor. Mönchengladbach | SC Freiburg | 0-6 | 1 - 3 points |