| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 24/09/21 19:30 | 24/09/21 19:15 | SpVgg Greuther Fürth | FC Bayern Munich | 1-3 | 2 - 4 points |
| 25/09/21 14:30 | 25/09/21 14:15 | Eintracht Frankfurt | 1. FC Köln | 1-1 | 2 - 4 points |
| 25/09/21 14:30 | 25/09/21 14:15 | RB Leipzig | Hertha BSC | 6-0 | 2 - 4 points |
| 25/09/21 14:30 | 25/09/21 14:15 | 1899 Hoffenheim | VfL Wolfsburg | 3-1 | 2 - 4 points |
| 25/09/21 14:30 | 25/09/21 14:15 | 1. FC Union Berlin | Arminia Bielefeld | 1-0 | 2 - 4 points |
| 25/09/21 14:30 | 25/09/21 14:15 | Bayer 04 Leverkusen | FSV Mainz 05 | 1-0 | 2 - 4 points |
| 25/09/21 17:30 | 25/09/21 17:15 | Bor. Mönchengladbach | Borussia Dortmund | 1-0 | 2 - 4 points |
| 26/09/21 14:30 | 26/09/21 14:15 | VfL Bochum | VfB Stuttgart | 0-0 | 2 - 4 points |
| 26/09/21 16:30 | 26/09/21 16:15 | SC Freiburg | FC Augsburg | 3-0 | 2 - 4 points |