| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 17/09/21 19:30 | 17/09/21 19:15 | Hertha BSC | SpVgg Greuther Fürth | 2-1 | 2 - 4 points |
| 18/09/21 14:30 | 18/09/21 14:15 | FC Bayern Munich | VfL Bochum | 7-0 | 2 - 4 points |
| 18/09/21 14:30 | 18/09/21 14:15 | Arminia Bielefeld | 1899 Hoffenheim | 0-0 | 2 - 4 points |
| 18/09/21 14:30 | 18/09/21 14:15 | FC Augsburg | Bor. Mönchengladbach | 1-0 | 2 - 4 points |
| 18/09/21 14:30 | 18/09/21 14:15 | FSV Mainz 05 | SC Freiburg | 0-0 | 2 - 4 points |
| 18/09/21 17:30 | 18/09/21 17:15 | 1. FC Köln | RB Leipzig | 1-1 | 2 - 4 points |
| 19/09/21 14:30 | 19/09/21 14:15 | VfB Stuttgart | Bayer 04 Leverkusen | 1-3 | 2 - 4 points |
| 19/09/21 16:30 | 19/09/21 16:15 | Borussia Dortmund | 1. FC Union Berlin | 4-2 | 2 - 4 points |
| 19/09/21 18:30 | 19/09/21 18:15 | VfL Wolfsburg | Eintracht Frankfurt | 1-1 | 2 - 4 points |