| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/09/21 14:30 | 11/09/21 14:15 | SpVgg Greuther Fürth | VfL Wolfsburg | 0-2 | 2 - 4 points |
| 11/09/21 14:30 | 11/09/21 14:15 | 1899 Hoffenheim | FSV Mainz 05 | 0-2 | 2 - 4 points |
| 11/09/21 14:30 | 11/09/21 14:15 | SC Freiburg | 1. FC Köln | 1-1 | 2 - 4 points |
| 11/09/21 14:30 | 11/09/21 14:15 | 1. FC Union Berlin | FC Augsburg | 0-0 | 2 - 4 points |
| 11/09/21 14:30 | 11/09/21 14:15 | Bayer 04 Leverkusen | Borussia Dortmund | 3-4 | 2 - 4 points |
| 11/09/21 17:30 | 11/09/21 17:15 | RB Leipzig | FC Bayern Munich | 1-4 | 2 - 4 points |
| 12/09/21 14:30 | 12/09/21 14:15 | Eintracht Frankfurt | VfB Stuttgart | 1-1 | 2 - 4 points |
| 12/09/21 16:30 | 12/09/21 16:15 | VfL Bochum | Hertha BSC | 1-3 | 2 - 4 points |
| 12/09/21 18:30 | 12/09/21 18:15 | Bor. Mönchengladbach | Arminia Bielefeld | 3-1 | 2 - 4 points |