| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 04/03/22 19:30 | 04/03/22 19:15 | Arminia Bielefeld | FC Augsburg | 0-1 | 2 - 4 points |
| 05/03/22 14:30 | 05/03/22 14:15 | Hertha BSC | Eintracht Frankfurt | 1-4 | 2 - 4 points |
| 05/03/22 14:30 | 05/03/22 14:15 | FC Bayern Munich | Bayer 04 Leverkusen | 1-1 | 2 - 4 points |
| 05/03/22 14:30 | 05/03/22 14:15 | VfL Wolfsburg | 1. FC Union Berlin | 1-0 | 2 - 4 points |
| 05/03/22 14:30 | 05/03/22 14:15 | RB Leipzig | SC Freiburg | 1-1 | 2 - 4 points |
| 05/03/22 14:30 | 05/03/22 14:15 | VfL Bochum | SpVgg Greuther Fürth | 2-1 | 2 - 4 points |
| 05/03/22 17:30 | 05/03/22 17:15 | VfB Stuttgart | Bor. Mönchengladbach | 3-2 | 2 - 4 points |
| 06/03/22 16:30 | 06/03/22 16:15 | 1. FC Köln | 1899 Hoffenheim | 0-1 | 2 - 4 points |
| 16/03/22 17:30 | 16/03/22 17:15 | FSV Mainz 05 | Borussia Dortmund | 0-1 | 2 - 4 points |