| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 04/02/22 19:30 | 04/02/22 19:15 | Hertha BSC | VfL Bochum | 1-1 | 2 - 4 points |
| 05/02/22 14:30 | 05/02/22 14:15 | VfB Stuttgart | Eintracht Frankfurt | 2-3 | 2 - 4 points |
| 05/02/22 14:30 | 05/02/22 14:15 | 1. FC Köln | SC Freiburg | 1-0 | 2 - 4 points |
| 05/02/22 14:30 | 05/02/22 14:15 | Arminia Bielefeld | Bor. Mönchengladbach | 1-1 | 2 - 4 points |
| 05/02/22 14:30 | 05/02/22 14:15 | FC Augsburg | 1. FC Union Berlin | 2-0 | 2 - 4 points |
| 05/02/22 14:30 | 05/02/22 14:15 | FSV Mainz 05 | 1899 Hoffenheim | 2-0 | 2 - 4 points |
| 05/02/22 17:30 | 05/02/22 17:15 | FC Bayern Munich | RB Leipzig | 3-2 | 2 - 4 points |
| 06/02/22 14:30 | 06/02/22 14:15 | Borussia Dortmund | Bayer 04 Leverkusen | 2-5 | 2 - 4 points |
| 06/02/22 16:30 | 06/02/22 16:15 | VfL Wolfsburg | SpVgg Greuther Fürth | 4-1 | 2 - 4 points |