| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 26/11/21 19:30 | 26/11/21 19:15 | VfB Stuttgart | FSV Mainz 05 | 2-1 | 2 - 4 points |
| 27/11/21 14:30 | 27/11/21 14:15 | 1. FC Köln | Bor. Mönchengladbach | 4-1 | 2 - 4 points |
| 27/11/21 14:30 | 27/11/21 14:15 | Hertha BSC | FC Augsburg | 1-1 | 2 - 4 points |
| 27/11/21 14:30 | 27/11/21 14:15 | VfL Wolfsburg | Borussia Dortmund | 1-3 | 2 - 4 points |
| 27/11/21 14:30 | 27/11/21 14:15 | SpVgg Greuther Fürth | 1899 Hoffenheim | 3-6 | 2 - 4 points |
| 27/11/21 14:30 | 27/11/21 14:15 | VfL Bochum | SC Freiburg | 2-1 | 2 - 4 points |
| 27/11/21 17:30 | 27/11/21 17:15 | FC Bayern Munich | Arminia Bielefeld | 1-0 | 2 - 4 points |
| 28/11/21 14:30 | 28/11/21 14:15 | Eintracht Frankfurt | 1. FC Union Berlin | 2-1 | 2 - 4 points |
| 28/11/21 16:30 | 28/11/21 16:15 | RB Leipzig | Bayer 04 Leverkusen | 1-3 | 2 - 4 points |