Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 05/11/21 20:00 | 05/11/21 20:00 | Atlantique Stade Rochelais | Union Bordeaux Bègles | 26-3 | 3 - 10 - 7 |
| 06/11/21 13:45 | 06/11/21 13:45 | Stade Toulousain | USA Perpignan | 37-15 | 3 - 10 - 10 |
| 06/11/21 13:45 | 06/11/21 13:45 | Section Paloise | Biarritz | 33-21 | 3 - 10 - 10 |
| 06/11/21 13:45 | 06/11/21 13:45 | Lyon OU | Castres Olympique | 30-23 | 3 - 10 - 10 |
| 06/11/21 13:45 | 06/11/21 13:45 | Stade Français | Montpellier Hérault RC | 27-31 | 4 - 10 - 5 |
| 06/11/21 16:00 | 06/11/21 16:00 | CA Brive | Racing Métro 92 | 12-10 | 4 - 10 - 4 |
| 07/11/21 20:05 | 07/11/21 20:05 | ASM Clermont Auvergne | RC Toulon | 31-16 | 3 - 10 - 10 |