Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 23/10/21 14:00 | 23/10/21 14:00 | Biarritz | CA Brive | 37-9 | 2 - 4 points |
| 23/10/21 14:00 | 23/10/21 14:00 | ASM Clermont Auvergne | Section Paloise | 42-20 | 2 - 4 points |
| 23/10/21 14:00 | 23/10/21 14:00 | Stade Français | Lyon OU | 23-18 | 2 - 4 points |
| 23/10/21 14:00 | 23/10/21 14:00 | Union Bordeaux Bègles | USA Perpignan | 39-13 | 2 - 4 points |
| 23/10/21 16:00 | 23/10/21 16:00 | Racing Métro 92 | Montpellier Hérault RC | 21-32 | 2 - 4 points |
| 23/10/21 20:00 | 23/10/21 20:00 | Stade Toulousain | Castres Olympique | 41-0 | 2 - 4 points |
| 24/10/21 20:05 | 24/10/21 20:05 | Atlantique Stade Rochelais | RC Toulon | 39-6 | 2 - 4 points |