Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 09/10/21 14:00 | 09/10/21 14:00 | Atlantique Stade Rochelais | Castres Olympique | 29-10 | 2 - 4 points |
| 09/10/21 14:00 | 09/10/21 14:00 | Union Bordeaux Bègles | Montpellier Hérault RC | 27-23 | 2 - 4 points |
| 09/10/21 14:00 | 09/10/21 14:00 | Racing Métro 92 | USA Perpignan | 17-14 | 2 - 4 points |
| 09/10/21 14:00 | 09/10/21 14:00 | Biarritz | Lyon OU | 5-40 | 2 - 4 points |
| 09/10/21 16:00 | 09/10/21 16:00 | Stade Toulousain | Section Paloise | 38-10 | 2 - 4 points |
| 09/10/21 20:05 | 09/10/21 20:05 | RC Toulon | CA Brive | 13-9 | 2 - 4 points |
| 10/10/21 20:10 | 10/10/21 20:10 | Stade Français | ASM Clermont Auvergne | 22-14 | 2 - 4 points |