Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 02/10/21 14:00 | 02/10/21 14:00 | Lyon OU | Union Bordeaux Bègles | 15-20 | 2 - 4 points |
| 02/10/21 14:00 | 02/10/21 14:00 | Montpellier Hérault RC | Atlantique Stade Rochelais | 21-11 | 2 - 4 points |
| 02/10/21 14:00 | 02/10/21 14:00 | USA Perpignan | Section Paloise | 14-29 | 2 - 4 points |
| 02/10/21 14:00 | 02/10/21 14:00 | CA Brive | Stade Français | 19-12 | 2 - 4 points |
| 02/10/21 16:00 | 02/10/21 16:00 | Biarritz | Stade Toulousain | 11-17 | 2 - 4 points |
| 02/10/21 20:05 | 02/10/21 20:05 | Castres Olympique | RC Toulon | 27-16 | 2 - 4 points |
| 03/10/21 20:05 | 03/10/21 20:05 | ASM Clermont Auvergne | Racing Métro 92 | 26-17 | 2 - 4 points |