Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 25/09/21 14:00 | 25/09/21 14:00 | Union Bordeaux Bègles | CA Brive | 29-10 | 2 - 4 points |
| 25/09/21 14:00 | 25/09/21 14:00 | Stade Français | Castres Olympique | 34-10 | 2 - 4 points |
| 25/09/21 14:00 | 25/09/21 14:00 | Atlantique Stade Rochelais | Biarritz | 59-17 | 2 - 4 points |
| 25/09/21 14:00 | 25/09/21 14:00 | Section Paloise | Montpellier Hérault RC | 23-22 | 2 - 4 points |
| 25/09/21 16:00 | 25/09/21 16:00 | Racing Métro 92 | Lyon OU | 24-20 | 2 - 4 points |
| 25/09/21 20:00 | 25/09/21 20:00 | USA Perpignan | RC Toulon | 12-9 | 2 - 4 points |
| 26/09/21 20:05 | 26/09/21 20:05 | Stade Toulousain | ASM Clermont Auvergne | 27-15 | 2 - 4 points |