Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 18/09/21 14:00 | 18/09/21 14:00 | CA Brive | Section Paloise | 30-13 | 2 - 4 points |
| 18/09/21 14:00 | 18/09/21 14:00 | Lyon OU | USA Perpignan | 47-3 | 2 - 4 points |
| 18/09/21 14:00 | 18/09/21 14:00 | Biarritz | Racing Métro 92 | 28-19 | 2 - 4 points |
| 18/09/21 14:00 | 18/09/21 14:00 | Castres Olympique | Union Bordeaux Bègles | 23-23 | 2 - 4 points |
| 18/09/21 16:00 | 18/09/21 16:00 | Montpellier Hérault RC | Stade Toulousain | 15-17 | 2 - 4 points |
| 18/09/21 20:05 | 18/09/21 20:05 | ASM Clermont Auvergne | Atlantique Stade Rochelais | 23-22 | 2 - 4 points |
| 19/09/21 20:10 | 19/09/21 20:10 | RC Toulon | Stade Français | 38-5 | 2 - 4 points |