Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 26/02/22 16:15 | 26/02/22 16:15 | Lyon OU | Biarritz | 34-15 | 2 - 4 points |
| 26/02/22 16:15 | 26/02/22 16:15 | ASM Clermont Auvergne | USA Perpignan | 52-12 | 2 - 4 points |
| 26/02/22 16:15 | 26/02/22 16:15 | Racing Métro 92 | Castres Olympique | 45-25 | 2 - 4 points |
| 26/02/22 16:15 | 26/02/22 16:15 | Section Paloise | Atlantique Stade Rochelais | 16-22 | 2 - 4 points |
| 26/02/22 20:05 | 26/02/22 20:05 | CA Brive | RC Toulon | 17-10 | 2 - 4 points |
| 27/02/22 16:30 | 27/02/22 16:30 | Montpellier Hérault RC | Stade Français | 30-3 | 2 - 4 points |
| 27/02/22 20:05 | 27/02/22 20:05 | Stade Toulousain | Union Bordeaux Bègles | 12-11 | 2 - 4 points |