Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 19/02/22 14:00 | 19/02/22 14:00 | Section Paloise | Stade Toulousain | 27-22 | 2 - 4 points |
| 19/02/22 16:00 | 19/02/22 16:00 | RC Toulon | USA Perpignan | 29-18 | 2 - 4 points |
| 19/02/22 16:00 | 19/02/22 16:00 | Stade Français | Biarritz | 65-19 | 2 - 4 points |
| 19/02/22 16:00 | 19/02/22 16:00 | CA Brive | Montpellier Hérault RC | 16-16 | 2 - 4 points |
| 19/02/22 16:00 | 19/02/22 16:00 | Castres Olympique | Lyon OU | 19-17 | 2 - 4 points |
| 19/02/22 20:05 | 19/02/22 20:05 | Atlantique Stade Rochelais | ASM Clermont Auvergne | 31-27 | 2 - 4 points |
| 20/02/22 20:05 | 20/02/22 20:05 | Union Bordeaux Bègles | Racing Métro 92 | 13-16 | 2 - 4 points |