Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 04/12/21 14:00 | 04/12/21 14:00 | ASM Clermont Auvergne | Biarritz | 39-11 | 2 - 4 points |
| 04/12/21 14:00 | 04/12/21 14:00 | Montpellier Hérault RC | USA Perpignan | 30-6 | 2 - 4 points |
| 04/12/21 14:00 | 04/12/21 14:00 | Lyon OU | CA Brive | 41-0 | 2 - 4 points |
| 04/12/21 14:00 | 04/12/21 14:00 | Castres Olympique | Racing Métro 92 | 25-3 | 2 - 4 points |
| 04/12/21 16:00 | 04/12/21 16:00 | Section Paloise | RC Toulon | 16-16 | 2 - 4 points |
| 04/12/21 20:05 | 04/12/21 20:05 | Union Bordeaux Bègles | Stade Toulousain | 17-7 | 2 - 4 points |
| 05/12/21 20:05 | 05/12/21 20:05 | Stade Français | Atlantique Stade Rochelais | 25-20 | 2 - 4 points |