Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 27/11/21 14:00 | 27/11/21 14:00 | Biarritz | Stade Français | 17-14 | 2 - 4 points |
| 27/11/21 14:00 | 27/11/21 14:00 | USA Perpignan | ASM Clermont Auvergne | 26-24 | 2 - 4 points |
| 27/11/21 14:00 | 27/11/21 14:00 | Montpellier Hérault RC | Castres Olympique | 25-24 | 2 - 4 points |
| 27/11/21 14:00 | 27/11/21 14:00 | Atlantique Stade Rochelais | Section Paloise | 36-8 | 2 - 4 points |
| 27/11/21 16:00 | 27/11/21 16:00 | RC Toulon | Lyon OU | 19-13 | 2 - 4 points |
| 27/11/21 20:05 | 27/11/21 20:05 | Stade Toulousain | CA Brive | 18-11 | 2 - 4 points |
| 28/11/21 20:05 | 28/11/21 20:05 | Racing Métro 92 | Union Bordeaux Bègles | 14-37 | 2 - 4 points |