Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 04/09/21 13:00 | 04/09/21 13:00 | Biarritz | Union Bordeaux Bègles | 27-15 | 2 - 4 points |
| 04/09/21 15:05 | 04/09/21 15:05 | CA Brive | USA Perpignan | 36-15 | 2 - 4 points |
| 04/09/21 15:05 | 04/09/21 15:05 | Castres Olympique | Section Paloise | 16-12 | 2 - 4 points |
| 04/09/21 17:15 | 04/09/21 17:15 | Stade Français | Racing Métro 92 | 21-36 | 2 - 4 points |
| 04/09/21 20:05 | 04/09/21 20:05 | RC Toulon | Montpellier Hérault RC | 24-24 | 2 - 4 points |
| 05/09/21 16:45 | 05/09/21 16:45 | Lyon OU | ASM Clermont Auvergne | 28-19 | 2 - 4 points |
| 05/09/21 20:05 | 05/09/21 20:05 | Atlantique Stade Rochelais | Stade Toulousain | 16-20 | 2 - 4 points |