| Date | Home | Away | Result |
|---|---|---|---|
| 01/10/21 19:30 | 1. FC Köln | SpVgg Greuther Fürth | 3-1 |
| 02/10/21 14:30 | Hertha BSC | SC Freiburg | 1-2 |
| 02/10/21 14:30 | VfB Stuttgart | 1899 Hoffenheim | 3-1 |
| 02/10/21 14:30 | VfL Wolfsburg | Bor. Mönchengladbach | 1-3 |
| 02/10/21 14:30 | Borussia Dortmund | FC Augsburg | 2-1 |
| 02/10/21 17:30 | RB Leipzig | VfL Bochum | 3-0 |
| 03/10/21 14:30 | FSV Mainz 05 | 1. FC Union Berlin | 1-2 |
| 03/10/21 16:30 | FC Bayern Munich | Eintracht Frankfurt | 1-2 |
| 03/10/21 18:30 | Arminia Bielefeld | Bayer 04 Leverkusen | 0-4 |