| Date | Home | Away | Result |
|---|---|---|---|
| 29/04/22 19:30 | 1. FC Union Berlin | SpVgg Greuther Fürth | 1-1 |
| 30/04/22 14:30 | Arminia Bielefeld | Hertha BSC | 1-1 |
| 30/04/22 14:30 | FC Augsburg | 1. FC Köln | 1-4 |
| 30/04/22 14:30 | FSV Mainz 05 | FC Bayern Munich | 3-1 |
| 30/04/22 14:30 | VfB Stuttgart | VfL Wolfsburg | 1-1 |
| 30/04/22 14:30 | Borussia Dortmund | VfL Bochum | 3-4 |
| 30/04/22 17:30 | 1899 Hoffenheim | SC Freiburg | 3-4 |
| 02/05/22 19:30 | Bor. Mönchengladbach | RB Leipzig | 3-1 |
| 02/05/22 19:30 | Bayer 04 Leverkusen | Eintracht Frankfurt | 2-0 |