| Date | Home | Away | Result |
|---|---|---|---|
| 11/02/22 19:30 | RB Leipzig | 1. FC Köln | 3-1 |
| 12/02/22 14:30 | Bor. Mönchengladbach | FC Augsburg | 3-2 |
| 12/02/22 14:30 | Eintracht Frankfurt | VfL Wolfsburg | 0-2 |
| 12/02/22 14:30 | SpVgg Greuther Fürth | Hertha BSC | 2-1 |
| 12/02/22 14:30 | VfL Bochum | FC Bayern Munich | 4-2 |
| 12/02/22 14:30 | SC Freiburg | FSV Mainz 05 | 1-1 |
| 12/02/22 17:30 | Bayer 04 Leverkusen | VfB Stuttgart | 4-2 |
| 13/02/22 14:30 | 1. FC Union Berlin | Borussia Dortmund | 0-3 |
| 13/02/22 16:30 | 1899 Hoffenheim | Arminia Bielefeld | 2-0 |