| Date | Home | Away | Result |
|---|---|---|---|
| 04/02/22 19:30 | Hertha BSC | VfL Bochum | 1-1 |
| 05/02/22 14:30 | VfB Stuttgart | Eintracht Frankfurt | 2-3 |
| 05/02/22 14:30 | 1. FC Köln | SC Freiburg | 1-0 |
| 05/02/22 14:30 | Arminia Bielefeld | Bor. Mönchengladbach | 1-1 |
| 05/02/22 14:30 | FC Augsburg | 1. FC Union Berlin | 2-0 |
| 05/02/22 14:30 | FSV Mainz 05 | 1899 Hoffenheim | 2-0 |
| 05/02/22 17:30 | FC Bayern Munich | RB Leipzig | 3-2 |
| 06/02/22 14:30 | Borussia Dortmund | Bayer 04 Leverkusen | 2-5 |
| 06/02/22 16:30 | VfL Wolfsburg | SpVgg Greuther Fürth | 4-1 |