| Date | Home | Away | Result |
|---|---|---|---|
| 11/09/21 14:30 | SpVgg Greuther Fürth | VfL Wolfsburg | 0-2 |
| 11/09/21 14:30 | 1899 Hoffenheim | FSV Mainz 05 | 0-2 |
| 11/09/21 14:30 | SC Freiburg | 1. FC Köln | 1-1 |
| 11/09/21 14:30 | 1. FC Union Berlin | FC Augsburg | 0-0 |
| 11/09/21 14:30 | Bayer 04 Leverkusen | Borussia Dortmund | 3-4 |
| 11/09/21 17:30 | RB Leipzig | FC Bayern Munich | 1-4 |
| 12/09/21 14:30 | Eintracht Frankfurt | VfB Stuttgart | 1-1 |
| 12/09/21 16:30 | VfL Bochum | Hertha BSC | 1-3 |
| 12/09/21 18:30 | Bor. Mönchengladbach | Arminia Bielefeld | 3-1 |