| Date | Home | Away | Result |
|---|---|---|---|
| 18/02/22 19:30 | FSV Mainz 05 | Bayer 04 Leverkusen | 3-2 |
| 19/02/22 14:30 | FC Augsburg | SC Freiburg | 1-2 |
| 19/02/22 14:30 | VfB Stuttgart | VfL Bochum | 1-1 |
| 19/02/22 14:30 | VfL Wolfsburg | 1899 Hoffenheim | 1-2 |
| 19/02/22 14:30 | Arminia Bielefeld | 1. FC Union Berlin | 1-0 |
| 19/02/22 17:30 | 1. FC Köln | Eintracht Frankfurt | 1-0 |
| 20/02/22 14:30 | FC Bayern Munich | SpVgg Greuther Fürth | 4-1 |
| 20/02/22 16:30 | Borussia Dortmund | Bor. Mönchengladbach | 6-0 |
| 20/02/22 18:30 | Hertha BSC | RB Leipzig | 1-6 |