| Date | Home | Away | Result |
|---|---|---|---|
| 22/10/21 19:30 | FSV Mainz 05 | FC Augsburg | 4-1 |
| 23/10/21 14:30 | RB Leipzig | SpVgg Greuther Fürth | 4-1 |
| 23/10/21 14:30 | FC Bayern Munich | 1899 Hoffenheim | 4-0 |
| 23/10/21 14:30 | Arminia Bielefeld | Borussia Dortmund | 1-3 |
| 23/10/21 14:30 | VfL Wolfsburg | SC Freiburg | 0-2 |
| 23/10/21 17:30 | Hertha BSC | Bor. Mönchengladbach | 1-0 |
| 24/10/21 14:30 | 1. FC Köln | Bayer 04 Leverkusen | 2-2 |
| 24/10/21 16:30 | VfB Stuttgart | 1. FC Union Berlin | 1-1 |
| 24/10/21 18:30 | VfL Bochum | Eintracht Frankfurt | 2-0 |