| Date | Home | Away | Result |
|---|---|---|---|
| 18/03/22 19:30 | VfL Bochum | Bor. Mönchengladbach | 0-2 |
| 19/03/22 14:30 | SpVgg Greuther Fürth | SC Freiburg | 0-0 |
| 19/03/22 14:30 | Hertha BSC | 1899 Hoffenheim | 3-0 |
| 19/03/22 14:30 | FSV Mainz 05 | Arminia Bielefeld | 4-0 |
| 19/03/22 14:30 | VfB Stuttgart | FC Augsburg | 3-2 |
| 19/03/22 17:30 | FC Bayern Munich | 1. FC Union Berlin | 4-0 |
| 20/03/22 14:30 | RB Leipzig | Eintracht Frankfurt | 0-0 |
| 20/03/22 16:30 | VfL Wolfsburg | Bayer 04 Leverkusen | 0-2 |
| 20/03/22 18:30 | 1. FC Köln | Borussia Dortmund | 1-1 |