| Date | Home | Away | Result |
|---|---|---|---|
| 07/01/22 19:30 | FC Bayern Munich | Bor. Mönchengladbach | 1-2 |
| 08/01/22 14:30 | SpVgg Greuther Fürth | VfB Stuttgart | 0-0 |
| 08/01/22 14:30 | 1899 Hoffenheim | FC Augsburg | 3-1 |
| 08/01/22 14:30 | SC Freiburg | Arminia Bielefeld | 2-2 |
| 08/01/22 14:30 | Bayer 04 Leverkusen | 1. FC Union Berlin | 2-2 |
| 08/01/22 14:30 | RB Leipzig | FSV Mainz 05 | 4-1 |
| 08/01/22 17:30 | Eintracht Frankfurt | Borussia Dortmund | 2-3 |
| 09/01/22 14:30 | Hertha BSC | 1. FC Köln | 1-3 |
| 09/01/22 16:30 | VfL Bochum | VfL Wolfsburg | 1-0 |