| Date | Home | Away | Result |
|---|---|---|---|
| 19/11/21 19:30 | FC Augsburg | FC Bayern Munich | 2-1 |
| 20/11/21 14:30 | Bor. Mönchengladbach | SpVgg Greuther Fürth | 4-0 |
| 20/11/21 14:30 | Bayer 04 Leverkusen | VfL Bochum | 1-0 |
| 20/11/21 14:30 | Borussia Dortmund | VfB Stuttgart | 2-1 |
| 20/11/21 14:30 | Arminia Bielefeld | VfL Wolfsburg | 2-2 |
| 20/11/21 14:30 | 1899 Hoffenheim | RB Leipzig | 2-0 |
| 20/11/21 17:30 | 1. FC Union Berlin | Hertha BSC | 2-0 |
| 21/11/21 14:30 | SC Freiburg | Eintracht Frankfurt | 0-2 |
| 21/11/21 16:30 | FSV Mainz 05 | 1. FC Köln | 1-1 |