Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 17/12/21 19:30 | 17/12/21 18:30 | FC Bayern Munich | VfL Wolfsburg | 4-0 | 2 - 4 points |
| 18/12/21 14:30 | 18/12/21 13:30 | 1899 Hoffenheim | Bor. Mönchengladbach | 1-1 | 2 - 4 points |
| 18/12/21 14:30 | 18/12/21 13:30 | Eintracht Frankfurt | FSV Mainz 05 | 1-0 | 2 - 4 points |
| 18/12/21 14:30 | 18/12/21 13:30 | RB Leipzig | Arminia Bielefeld | 0-2 | 2 - 4 points |
| 18/12/21 14:30 | 18/12/21 13:30 | SpVgg Greuther Fürth | FC Augsburg | 0-0 | 2 - 4 points |
| 18/12/21 14:30 | 18/12/21 13:30 | VfL Bochum | 1. FC Union Berlin | 0-1 | 2 - 4 points |
| 18/12/21 17:30 | 18/12/21 16:30 | Hertha BSC | Borussia Dortmund | 3-2 | 2 - 4 points |
| 19/12/21 14:30 | 19/12/21 13:30 | SC Freiburg | Bayer 04 Leverkusen | 2-1 | 2 - 4 points |
| 19/12/21 16:30 | 19/12/21 15:30 | 1. FC Köln | VfB Stuttgart | 1-0 | 2 - 4 points |