Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 28/10/22 01:15 | 28/10/22 01:15 | Tampa Bay Buccaneers | Baltimore Ravens | 22-27 | 4 - 10 - 4 |
| 30/10/22 13:30 | 30/10/22 13:30 | Jacksonville Jaguars | Denver Broncos | 17-21 | 4 - 10 - 4 |
| 30/10/22 17:00 | 30/10/22 17:00 | Dallas Cowboys | Chicago Bears | 49-29 | 3 - 10 - 8 |
| 30/10/22 17:00 | 30/10/22 17:00 | Atlanta Falcons | Carolina Panthers | 37-34OT | 3 - 10 - 6 |
| 30/10/22 17:00 | 30/10/22 17:00 | New York Jets | New England Patriots | 17-22 | 4 - 10 - 4 |
| 30/10/22 17:00 | 30/10/22 17:00 | Detroit Lions | Miami Dolphins | 27-31 | 8 - 10 - 3 |
| 30/10/22 17:00 | 30/10/22 17:00 | Philadelphia Eagles | Pittsburgh Steelers | 35-13 | 3 - 10 - 10 |
| 30/10/22 17:00 | 30/10/22 17:00 | New Orleans Saints | Las Vegas Raiders | 24-0 | 5 - 10 - 4 |
| 30/10/22 17:00 | 30/10/22 17:00 | Minnesota Vikings | Arizona Cardinals | 34-26 | 3 - 10 - 6 |
| 30/10/22 20:05 | 30/10/22 20:05 | Houston Texans | Tennessee Titans | 10-17 | 8 - 10 - 3 |
| 30/10/22 20:25 | 30/10/22 20:25 | Indianapolis Colts | Washington Commanders | 16-17 | 4 - 10 - 5 |
| 30/10/22 20:25 | 30/10/22 20:25 | Seattle Seahawks | New York Giants | 27-13 | 4 - 10 - 4 |
| 30/10/22 20:25 | 30/10/22 20:25 | Los Angeles Rams | San Francisco 49ers | 14-31 | 4 - 10 - 4 |
| 31/10/22 00:20 | 31/10/22 00:20 | Buffalo Bills | Green Bay Packers | 27-17 | 3 - 10 - 10 |
| 01/11/22 00:15 | 01/11/22 00:15 | Cleveland Browns | Cincinnati Bengals | 32-13 | 7 - 10 - 3 |