Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 29/10/21 01:20 | 29/10/21 01:20 | Arizona Cardinals | Green Bay Packers | 21-24 | 4 - 10 - 5 |
| 31/10/21 17:00 | 31/10/21 17:00 | Buffalo Bills | Miami Dolphins | 26-11 | 3 - 10 - 10 |
| 31/10/21 17:00 | 31/10/21 17:00 | Atlanta Falcons | Carolina Panthers | 13-19 | 3 - 10 - 6 |
| 31/10/21 17:00 | 31/10/21 17:00 | Chicago Bears | San Francisco 49ers | 22-33 | 5 - 10 - 3 |
| 31/10/21 17:00 | 31/10/21 17:00 | Detroit Lions | Philadelphia Eagles | 6-44 | 5 - 10 - 4 |
| 31/10/21 17:00 | 31/10/21 17:00 | Cleveland Browns | Pittsburgh Steelers | 10-15 | 3 - 10 - 6 |
| 31/10/21 17:00 | 31/10/21 17:00 | Houston Texans | Los Angeles Rams | 22-38 | 10 - 10 - 3 |
| 31/10/21 17:00 | 31/10/21 17:00 | Indianapolis Colts | Tennessee Titans | 31-34OT | 6 - 10 - 3 |
| 31/10/21 17:00 | 31/10/21 17:00 | New York Jets | Cincinnati Bengals | 34-31 | 10 - 10 - 3 |
| 31/10/21 20:05 | 31/10/21 20:05 | Seattle Seahawks | Jacksonville Jaguars | 31-7 | 3 - 10 - 7 |
| 31/10/21 20:05 | 31/10/21 20:05 | Los Angeles Chargers | New England Patriots | 24-27 | 3 - 10 - 6 |
| 31/10/21 20:25 | 31/10/21 20:25 | New Orleans Saints | Tampa Bay Buccaneers | 36-27 | 7 - 10 - 3 |
| 31/10/21 20:25 | 31/10/21 20:25 | Denver Broncos | Washington Football Team | 17-10 | 4 - 10 - 5 |
| 01/11/21 00:20 | 01/11/21 00:20 | Minnesota Vikings | Dallas Cowboys | 16-20 | 6 - 10 - 3 |
| 02/11/21 00:15 | 02/11/21 00:15 | Kansas City Chiefs | New York Giants | 20-17 | 3 - 10 - 10 |