Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 15/10/21 01:20 | 15/10/21 01:20 | Philadelphia Eagles | Tampa Bay Buccaneers | 22-28 | 10 - 10 - 3 |
| 17/10/21 14:30 | 17/10/21 14:30 | Jacksonville Jaguars | Miami Dolphins | 23-20 | 4 - 10 - 4 |
| 17/10/21 18:00 | 17/10/21 18:00 | Carolina Panthers | Minnesota Vikings | 28-34OT | 4 - 10 - 4 |
| 17/10/21 18:00 | 17/10/21 18:00 | Baltimore Ravens | Los Angeles Chargers | 34-6 | 4 - 10 - 4 |
| 17/10/21 18:00 | 17/10/21 18:00 | Chicago Bears | Green Bay Packers | 14-24 | 9 - 10 - 3 |
| 17/10/21 18:00 | 17/10/21 18:00 | Detroit Lions | Cincinnati Bengals | 11-34 | 7 - 10 - 3 |
| 17/10/21 18:00 | 17/10/21 18:00 | Indianapolis Colts | Houston Texans | 31-3 | 3 - 10 - 10 |
| 17/10/21 18:00 | 17/10/21 18:00 | New York Giants | Los Angeles Rams | 11-38 | 10 - 10 - 3 |
| 17/10/21 18:00 | 17/10/21 18:00 | Washington Football Team | Kansas City Chiefs | 13-31 | 10 - 10 - 3 |
| 17/10/21 21:05 | 17/10/21 21:05 | Cleveland Browns | Arizona Cardinals | 14-37 | 4 - 10 - 4 |
| 17/10/21 21:25 | 17/10/21 21:25 | New England Patriots | Dallas Cowboys | 29-35OT | 7 - 10 - 3 |
| 17/10/21 21:25 | 17/10/21 21:25 | Denver Broncos | Las Vegas Raiders | 24-34 | 4 - 10 - 5 |
| 18/10/21 01:20 | 18/10/21 01:20 | Pittsburgh Steelers | Seattle Seahawks | 23-20OT | 4 - 10 - 5 |
| 19/10/21 01:15 | 19/10/21 01:15 | Tennessee Titans | Buffalo Bills | 34-31 | 10 - 10 - 3 |