Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 23/09/22 01:15 | 23/09/22 01:15 | Cleveland Browns | Pittsburgh Steelers | 29-17 | 4 - 10 - 5 |
| 25/09/22 18:00 | 25/09/22 18:00 | Washington Commanders | Philadelphia Eagles | 8-24 | 7 - 10 - 3 |
| 25/09/22 18:00 | 25/09/22 18:00 | Tennessee Titans | Las Vegas Raiders | 24-22 | 5 - 10 - 4 |
| 25/09/22 18:00 | 25/09/22 18:00 | New England Patriots | Baltimore Ravens | 26-37 | 5 - 10 - 4 |
| 25/09/22 18:00 | 25/09/22 18:00 | New York Jets | Cincinnati Bengals | 12-27 | 7 - 10 - 3 |
| 25/09/22 18:00 | 25/09/22 18:00 | Carolina Panthers | New Orleans Saints | 22-14 | 6 - 10 - 3 |
| 25/09/22 18:00 | 25/09/22 18:00 | Minnesota Vikings | Detroit Lions | 28-24 | 3 - 10 - 5 |
| 25/09/22 18:00 | 25/09/22 18:00 | Miami Dolphins | Buffalo Bills | 21-19 | 6 - 10 - 3 |
| 25/09/22 18:00 | 25/09/22 18:00 | Indianapolis Colts | Kansas City Chiefs | 20-17 | 10 - 10 - 3 |
| 25/09/22 18:00 | 25/09/22 18:00 | Chicago Bears | Houston Texans | 23-20 | 3 - 10 - 8 |
| 25/09/22 21:05 | 25/09/22 21:05 | Los Angeles Chargers | Jacksonville Jaguars | 10-38 | 3 - 10 - 10 |
| 25/09/22 21:25 | 25/09/22 21:25 | Tampa Bay Buccaneers | Green Bay Packers | 12-14 | 4 - 10 - 5 |
| 25/09/22 21:25 | 25/09/22 21:25 | Seattle Seahawks | Atlanta Falcons | 23-27 | 4 - 10 - 4 |
| 25/09/22 21:25 | 25/09/22 21:25 | Arizona Cardinals | Los Angeles Rams | 12-20 | 7 - 10 - 3 |
| 26/09/22 01:20 | 26/09/22 01:20 | Denver Broncos | San Francisco 49ers | 11-10 | 5 - 10 - 4 |
| 27/09/22 01:15 | 27/09/22 01:15 | New York Giants | Dallas Cowboys | 16-23 | 4 - 10 - 4 |