Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 16/09/22 01:15 | 16/09/22 01:15 | Kansas City Chiefs | Los Angeles Chargers | 27-24 | 3 - 10 - 10 |
| 18/09/22 18:00 | 18/09/22 18:00 | New York Giants | Carolina Panthers | 19-16 | 4 - 10 - 4 |
| 18/09/22 18:00 | 18/09/22 18:00 | Jacksonville Jaguars | Indianapolis Colts | 24-0 | 8 - 10 - 3 |
| 18/09/22 18:00 | 18/09/22 18:00 | Cleveland Browns | New York Jets | 30-31 | 3 - 10 - 10 |
| 18/09/22 18:00 | 18/09/22 18:00 | Detroit Lions | Washington Commanders | 36-27 | 4 - 10 - 4 |
| 18/09/22 18:00 | 18/09/22 18:00 | New Orleans Saints | Tampa Bay Buccaneers | 10-20 | 6 - 10 - 3 |
| 18/09/22 18:00 | 18/09/22 18:00 | Pittsburgh Steelers | New England Patriots | 14-17 | 3 - 10 - 6 |
| 18/09/22 18:00 | 18/09/22 18:00 | Baltimore Ravens | Miami Dolphins | 38-42 | 4 - 10 - 5 |
| 18/09/22 21:05 | 18/09/22 21:05 | San Francisco 49ers | Seattle Seahawks | 27-7 | 3 - 10 - 8 |
| 18/09/22 21:05 | 18/09/22 21:05 | Los Angeles Rams | Atlanta Falcons | 31-27 | 3 - 10 - 10 |
| 18/09/22 21:25 | 18/09/22 21:25 | Dallas Cowboys | Cincinnati Bengals | 20-17 | 7 - 10 - 3 |
| 18/09/22 21:25 | 18/09/22 21:25 | Denver Broncos | Houston Texans | 16-9 | 3 - 10 - 10 |
| 18/09/22 21:25 | 18/09/22 21:25 | Las Vegas Raiders | Arizona Cardinals | 23-29OT | 3 - 10 - 5 |
| 19/09/22 01:20 | 19/09/22 01:20 | Green Bay Packers | Chicago Bears | 27-10 | 3 - 10 - 7 |
| 20/09/22 00:15 | 20/09/22 00:15 | Buffalo Bills | Tennessee Titans | 41-7 | 3 - 10 - 10 |
| 20/09/22 01:30 | 20/09/22 01:30 | Philadelphia Eagles | Minnesota Vikings | 24-7 | 5 - 10 - 4 |