Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 17/09/21 01:20 | 17/09/21 01:20 | Washington Football Team | New York Giants | 30-29 | 3 - 10 - 5 |
| 19/09/21 18:00 | 19/09/21 18:00 | Chicago Bears | Cincinnati Bengals | 20-17 | 4 - 10 - 4 |
| 19/09/21 18:00 | 19/09/21 18:00 | Pittsburgh Steelers | Las Vegas Raiders | 17-26 | 3 - 10 - 6 |
| 19/09/21 18:00 | 19/09/21 18:00 | Indianapolis Colts | Los Angeles Rams | 24-27 | 10 - 10 - 3 |
| 19/09/21 18:00 | 19/09/21 18:00 | Philadelphia Eagles | San Francisco 49ers | 11-17 | 6 - 10 - 3 |
| 19/09/21 18:00 | 19/09/21 18:00 | Miami Dolphins | Buffalo Bills | 0-35 | 8 - 10 - 3 |
| 19/09/21 18:00 | 19/09/21 18:00 | Jacksonville Jaguars | Denver Broncos | 13-23 | 5 - 10 - 3 |
| 19/09/21 18:00 | 19/09/21 18:00 | New York Jets | New England Patriots | 6-25 | 8 - 10 - 3 |
| 19/09/21 18:00 | 19/09/21 18:00 | Carolina Panthers | New Orleans Saints | 26-7 | 9 - 10 - 3 |
| 19/09/21 18:00 | 19/09/21 18:00 | Cleveland Browns | Houston Texans | 31-21 | 3 - 10 - 7 |
| 19/09/21 21:05 | 19/09/21 21:05 | Tampa Bay Buccaneers | Atlanta Falcons | 48-25 | 3 - 10 - 10 |
| 19/09/21 21:05 | 19/09/21 21:05 | Arizona Cardinals | Minnesota Vikings | 34-33 | 3 - 10 - 6 |
| 19/09/21 21:25 | 19/09/21 21:25 | Los Angeles Chargers | Dallas Cowboys | 17-20 | 5 - 10 - 3 |
| 19/09/21 21:25 | 19/09/21 21:25 | Seattle Seahawks | Tennessee Titans | 30-33OT | 3 - 10 - 8 |
| 20/09/21 01:20 | 20/09/21 01:20 | Baltimore Ravens | Kansas City Chiefs | 36-35 | 8 - 10 - 3 |
| 21/09/21 01:15 | 21/09/21 01:15 | Green Bay Packers | Detroit Lions | 35-17 | 3 - 10 - 8 |