Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 08/01/22 21:30 | 08/01/22 21:30 | Denver Broncos | Kansas City Chiefs | 24-28 | 10 - 10 - 3 |
| 09/01/22 01:15 | 09/01/22 01:15 | Philadelphia Eagles | Dallas Cowboys | 26-51 | 5 - 10 - 3 |
| 09/01/22 18:00 | 09/01/22 18:00 | New York Giants | Washington Football Team | 7-22 | 7 - 10 - 3 |
| 09/01/22 18:00 | 09/01/22 18:00 | Jacksonville Jaguars | Indianapolis Colts | 26-11 | 10 - 10 - 3 |
| 09/01/22 18:00 | 09/01/22 18:00 | Detroit Lions | Green Bay Packers | 37-30 | 8 - 10 - 3 |
| 09/01/22 18:00 | 09/01/22 18:00 | Cleveland Browns | Cincinnati Bengals | 21-16 | 5 - 10 - 4 |
| 09/01/22 18:00 | 09/01/22 18:00 | Baltimore Ravens | Pittsburgh Steelers | 13-16OT | 4 - 10 - 4 |
| 09/01/22 18:00 | 09/01/22 18:00 | Houston Texans | Tennessee Titans | 25-28 | 10 - 10 - 3 |
| 09/01/22 18:00 | 09/01/22 18:00 | Minnesota Vikings | Chicago Bears | 31-17 | 3 - 10 - 6 |
| 09/01/22 21:25 | 09/01/22 21:25 | Arizona Cardinals | Seattle Seahawks | 30-38 | 3 - 10 - 10 |
| 09/01/22 21:25 | 09/01/22 21:25 | Los Angeles Rams | San Francisco 49ers | 24-27OT | 3 - 10 - 7 |
| 09/01/22 21:25 | 09/01/22 21:25 | Buffalo Bills | New York Jets | 27-10 | 3 - 10 - 10 |
| 09/01/22 21:25 | 09/01/22 21:25 | Atlanta Falcons | New Orleans Saints | 20-30 | 8 - 10 - 3 |
| 09/01/22 21:25 | 09/01/22 21:25 | Miami Dolphins | New England Patriots | 33-24 | 6 - 10 - 3 |
| 09/01/22 21:25 | 09/01/22 21:25 | Tampa Bay Buccaneers | Carolina Panthers | 41-17 | 3 - 10 - 10 |
| 10/01/22 01:20 | 10/01/22 01:20 | Las Vegas Raiders | Los Angeles Chargers | 35-32OT | 5 - 10 - 3 |