Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 02/01/22 18:00 | 02/01/22 18:00 | New York Jets | Tampa Bay Buccaneers | 24-28 | 10 - 10 - 3 |
| 02/01/22 18:00 | 02/01/22 18:00 | Washington Football Team | Philadelphia Eagles | 16-20 | 6 - 10 - 3 |
| 02/01/22 18:00 | 02/01/22 18:00 | Baltimore Ravens | Los Angeles Rams | 19-20 | 6 - 10 - 3 |
| 02/01/22 18:00 | 02/01/22 18:00 | Buffalo Bills | Atlanta Falcons | 29-15 | 3 - 10 - 10 |
| 02/01/22 18:00 | 02/01/22 18:00 | Chicago Bears | New York Giants | 29-3 | 3 - 10 - 8 |
| 02/01/22 18:00 | 02/01/22 18:00 | Cincinnati Bengals | Kansas City Chiefs | 34-31 | 6 - 10 - 3 |
| 02/01/22 18:00 | 02/01/22 18:00 | Indianapolis Colts | Las Vegas Raiders | 20-23 | 3 - 10 - 10 |
| 02/01/22 18:00 | 02/01/22 18:00 | New England Patriots | Jacksonville Jaguars | 50-10 | 3 - 10 - 10 |
| 02/01/22 18:00 | 02/01/22 18:00 | Tennessee Titans | Miami Dolphins | 34-3 | 4 - 10 - 5 |
| 02/01/22 21:05 | 02/01/22 21:05 | Los Angeles Chargers | Denver Broncos | 34-13 | 3 - 10 - 10 |
| 02/01/22 21:05 | 02/01/22 21:05 | San Francisco 49ers | Houston Texans | 23-7 | 3 - 10 - 10 |
| 02/01/22 21:25 | 02/01/22 21:25 | New Orleans Saints | Carolina Panthers | 18-10 | 3 - 10 - 8 |
| 02/01/22 21:25 | 02/01/22 21:25 | Seattle Seahawks | Detroit Lions | 51-29 | 3 - 10 - 7 |
| 02/01/22 21:25 | 02/01/22 21:25 | Dallas Cowboys | Arizona Cardinals | 22-25 | 3 - 10 - 6 |
| 03/01/22 01:20 | 03/01/22 01:20 | Green Bay Packers | Minnesota Vikings | 37-10 | 3 - 10 - 10 |
| 04/01/22 01:15 | 04/01/22 01:15 | Pittsburgh Steelers | Cleveland Browns | 26-14 | 4 - 10 - 4 |