Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/12/21 01:20 | 10/12/21 01:20 | Minnesota Vikings | Pittsburgh Steelers | 36-28 | 4 - 10 - 5 |
| 12/12/21 18:00 | 12/12/21 18:00 | Cleveland Browns | Baltimore Ravens | 24-22 | 5 - 10 - 4 |
| 12/12/21 18:00 | 12/12/21 18:00 | Carolina Panthers | Atlanta Falcons | 21-29 | 4 - 10 - 5 |
| 12/12/21 18:00 | 12/12/21 18:00 | New York Jets | New Orleans Saints | 9-30 | 7 - 10 - 3 |
| 12/12/21 18:00 | 12/12/21 18:00 | Kansas City Chiefs | Las Vegas Raiders | 48-9 | 3 - 10 - 10 |
| 12/12/21 18:00 | 12/12/21 18:00 | Houston Texans | Seattle Seahawks | 13-33 | 10 - 10 - 3 |
| 12/12/21 18:00 | 12/12/21 18:00 | Tennessee Titans | Jacksonville Jaguars | 20-0 | 3 - 10 - 10 |
| 12/12/21 18:00 | 12/12/21 18:00 | Washington Football Team | Dallas Cowboys | 20-27 | 6 - 10 - 3 |
| 12/12/21 21:05 | 12/12/21 21:05 | Denver Broncos | Detroit Lions | 38-10 | 3 - 10 - 10 |
| 12/12/21 21:05 | 12/12/21 21:05 | Los Angeles Chargers | New York Giants | 37-21 | 3 - 10 - 10 |
| 12/12/21 21:25 | 12/12/21 21:25 | Tampa Bay Buccaneers | Buffalo Bills | 33-27OT | 3 - 10 - 7 |
| 12/12/21 21:25 | 12/12/21 21:25 | Cincinnati Bengals | San Francisco 49ers | 23-26OT | 4 - 10 - 4 |
| 13/12/21 01:20 | 13/12/21 01:20 | Green Bay Packers | Chicago Bears | 45-30 | 3 - 10 - 10 |
| 14/12/21 01:15 | 14/12/21 01:15 | Arizona Cardinals | Los Angeles Rams | 23-30 | 3 - 10 - 6 |