Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 12/11/21 01:20 | 12/11/21 01:20 | Miami Dolphins | Baltimore Ravens | 22-10 | 10 - 10 - 3 |
| 14/11/21 18:00 | 14/11/21 18:00 | New England Patriots | Cleveland Browns | 45-7 | 4 - 10 - 4 |
| 14/11/21 18:00 | 14/11/21 18:00 | Pittsburgh Steelers | Detroit Lions | 16-16OT | 3 - 10 - 10 |
| 14/11/21 18:00 | 14/11/21 18:00 | Indianapolis Colts | Jacksonville Jaguars | 23-17 | 3 - 10 - 10 |
| 14/11/21 18:00 | 14/11/21 18:00 | Tennessee Titans | New Orleans Saints | 23-21 | 4 - 10 - 5 |
| 14/11/21 18:00 | 14/11/21 18:00 | Dallas Cowboys | Atlanta Falcons | 43-3 | 3 - 10 - 10 |
| 14/11/21 18:00 | 14/11/21 18:00 | Washington Football Team | Tampa Bay Buccaneers | 29-19 | 10 - 10 - 3 |
| 14/11/21 18:00 | 14/11/21 18:00 | New York Jets | Buffalo Bills | 17-45 | 10 - 10 - 3 |
| 14/11/21 21:05 | 14/11/21 21:05 | Arizona Cardinals | Carolina Panthers | 10-34 | 3 - 10 - 10 |
| 14/11/21 21:05 | 14/11/21 21:05 | Los Angeles Chargers | Minnesota Vikings | 20-27 | 3 - 10 - 6 |
| 14/11/21 21:25 | 14/11/21 21:25 | Green Bay Packers | Seattle Seahawks | 17-0 | 3 - 10 - 5 |
| 14/11/21 21:25 | 14/11/21 21:25 | Denver Broncos | Philadelphia Eagles | 13-30 | 3 - 10 - 5 |
| 15/11/21 01:20 | 15/11/21 01:20 | Las Vegas Raiders | Kansas City Chiefs | 14-41 | 5 - 10 - 4 |
| 16/11/21 01:15 | 16/11/21 01:15 | San Francisco 49ers | Los Angeles Rams | 31-10 | 10 - 10 - 3 |