Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/09/21 01:20 | 10/09/21 01:20 | Tampa Bay Buccaneers | Dallas Cowboys | 31-29 | 3 - 10 - 10 |
| 12/09/21 18:00 | 12/09/21 18:00 | Houston Texans | Jacksonville Jaguars | 37-21 | 5 - 10 - 4 |
| 12/09/21 18:00 | 12/09/21 18:00 | Detroit Lions | San Francisco 49ers | 33-41 | 10 - 10 - 3 |
| 12/09/21 18:00 | 12/09/21 18:00 | Cincinnati Bengals | Minnesota Vikings | 27-24OT | 6 - 10 - 3 |
| 12/09/21 18:00 | 12/09/21 18:00 | Carolina Panthers | New York Jets | 19-14 | 3 - 10 - 7 |
| 12/09/21 18:00 | 12/09/21 18:00 | Buffalo Bills | Pittsburgh Steelers | 16-23 | 3 - 10 - 8 |
| 12/09/21 18:00 | 12/09/21 18:00 | Atlanta Falcons | Philadelphia Eagles | 6-32 | 4 - 10 - 5 |
| 12/09/21 18:00 | 12/09/21 18:00 | Washington Football Team | Los Angeles Chargers | 16-20 | 5 - 10 - 4 |
| 12/09/21 18:00 | 12/09/21 18:00 | Tennessee Titans | Arizona Cardinals | 13-38 | 3 - 10 - 6 |
| 12/09/21 18:00 | 12/09/21 18:00 | Indianapolis Colts | Seattle Seahawks | 16-28 | 6 - 10 - 3 |
| 12/09/21 21:25 | 12/09/21 21:25 | New York Giants | Denver Broncos | 13-27 | 4 - 10 - 4 |
| 12/09/21 21:25 | 12/09/21 21:25 | New Orleans Saints | Green Bay Packers | 38-3 | 7 - 10 - 3 |
| 12/09/21 21:25 | 12/09/21 21:25 | New England Patriots | Miami Dolphins | 16-17 | 4 - 10 - 4 |
| 12/09/21 21:25 | 12/09/21 21:25 | Kansas City Chiefs | Cleveland Browns | 33-29 | 3 - 10 - 10 |
| 13/09/21 01:20 | 13/09/21 01:20 | Los Angeles Rams | Chicago Bears | 34-14 | 3 - 10 - 10 |
| 14/09/21 01:15 | 14/09/21 01:15 | Las Vegas Raiders | Baltimore Ravens | 33-27OT | 7 - 10 - 3 |