Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| NFL | 15/10/21 01:20 | 15/10/21 01:18 | Philadelphia Eagles | Tampa Bay Buccaneers | 22-28 | 5 - 25 points |
| NFL | 17/10/21 14:30 | 17/10/21 14:28 | Jacksonville Jaguars | Miami Dolphins | 23-20 | 5 - 25 points |
| NFL | 17/10/21 18:00 | 17/10/21 17:58 | Carolina Panthers | Minnesota Vikings | 28-34OT | 5 - 25 points |
| NFL | 17/10/21 18:00 | 17/10/21 17:58 | Baltimore Ravens | Los Angeles Chargers | 34-6 | 5 - 25 points |
| NFL | 17/10/21 18:00 | 17/10/21 17:58 | Chicago Bears | Green Bay Packers | 14-24 | 5 - 25 points |
| NFL | 17/10/21 18:00 | 17/10/21 17:58 | Detroit Lions | Cincinnati Bengals | 11-34 | 5 - 25 points |
| NFL | 17/10/21 18:00 | 17/10/21 17:58 | Indianapolis Colts | Houston Texans | 31-3 | 5 - 25 points |
| NFL | 17/10/21 18:00 | 17/10/21 17:58 | New York Giants | Los Angeles Rams | 11-38 | 5 - 25 points |
| NFL | 17/10/21 18:00 | 17/10/21 17:58 | Washington Football Team | Kansas City Chiefs | 13-31 | 5 - 25 points |
| NFL | 17/10/21 21:05 | 17/10/21 21:03 | Cleveland Browns | Arizona Cardinals | 14-37 | 5 - 25 points |
| NFL | 17/10/21 21:25 | 17/10/21 21:23 | New England Patriots | Dallas Cowboys | 29-35OT | 5 - 25 points |
| NFL | 17/10/21 21:25 | 17/10/21 21:23 | Denver Broncos | Las Vegas Raiders | 24-34 | 5 - 25 points |
| NFL | 18/10/21 01:20 | 18/10/21 01:18 | Pittsburgh Steelers | Seattle Seahawks | 23-20OT | 5 - 25 points |
| NFL | 19/10/21 01:15 | 19/10/21 01:13 | Tennessee Titans | Buffalo Bills | 34-31 | 5 - 25 points |