Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| NFL | 24/09/21 01:20 | 24/09/21 01:18 | Houston Texans | Carolina Panthers | 9-24 | 5 - 25 points |
| NFL | 26/09/21 18:00 | 26/09/21 17:58 | Jacksonville Jaguars | Arizona Cardinals | 19-31 | 5 - 25 points |
| NFL | 26/09/21 18:00 | 26/09/21 17:58 | New England Patriots | New Orleans Saints | 13-28 | 5 - 25 points |
| NFL | 26/09/21 18:00 | 26/09/21 17:58 | Detroit Lions | Baltimore Ravens | 17-19 | 5 - 25 points |
| NFL | 26/09/21 18:00 | 26/09/21 17:58 | Cleveland Browns | Chicago Bears | 26-6 | 5 - 25 points |
| NFL | 26/09/21 18:00 | 26/09/21 17:58 | Pittsburgh Steelers | Cincinnati Bengals | 10-24 | 5 - 25 points |
| NFL | 26/09/21 18:00 | 26/09/21 17:58 | Kansas City Chiefs | Los Angeles Chargers | 24-30 | 5 - 25 points |
| NFL | 26/09/21 18:00 | 26/09/21 17:58 | New York Giants | Atlanta Falcons | 14-17 | 5 - 25 points |
| NFL | 26/09/21 18:00 | 26/09/21 17:58 | Tennessee Titans | Indianapolis Colts | 25-16 | 5 - 25 points |
| NFL | 26/09/21 18:00 | 26/09/21 17:58 | Buffalo Bills | Washington Football Team | 43-21 | 5 - 25 points |
| NFL | 26/09/21 21:05 | 26/09/21 21:03 | Las Vegas Raiders | Miami Dolphins | 31-28OT | 5 - 25 points |
| NFL | 26/09/21 21:05 | 26/09/21 21:03 | Denver Broncos | New York Jets | 26-0 | 5 - 25 points |
| NFL | 26/09/21 21:25 | 26/09/21 21:23 | Los Angeles Rams | Tampa Bay Buccaneers | 34-24 | 5 - 25 points |
| NFL | 26/09/21 21:25 | 26/09/21 21:23 | Minnesota Vikings | Seattle Seahawks | 30-17 | 5 - 25 points |
| NFL | 27/09/21 01:20 | 27/09/21 01:18 | San Francisco 49ers | Green Bay Packers | 28-30 | 5 - 25 points |
| NFL | 28/09/21 01:15 | 28/09/21 01:13 | Dallas Cowboys | Philadelphia Eagles | 41-21 | 5 - 25 points |