Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| DFB | 26/10/21 19:45 | 26/10/21 19:30 | 1. FC Nürnberg | Hamburger SV | 3-5a.PSO | 1 - 2 points |
| DFB | 26/10/21 19:45 | 26/10/21 19:30 | FSV Mainz 05 | Arminia Bielefeld | 3-2a.e.t | 1 - 2 points |
| DFB | 27/10/21 17:30 | 27/10/21 17:15 | VfL Bochum | FC Augsburg | 7-6a.PSO | 1 - 2 points |
| DFB | 27/10/21 19:45 | 27/10/21 19:30 | Bor. Mönchengladbach | FC Bayern Munich | 5-0 | 1 - 2 points |
| DFB | 27/10/21 19:45 | 27/10/21 19:30 | VfB Stuttgart | 1. FC Köln | 0-2 | 1 - 2 points |
| 2.BL | 29/10/21 17:30 | 29/10/21 17:15 | 1. FC Heidenheim 1846 | FC Schalke 04 | 1-0 | 1 - 2 points |
| GER1 | 29/10/21 19:30 | 29/10/21 19:15 | 1899 Hoffenheim | Hertha BSC | 2-0 | 1 - 2 points |
| 2.BL | 30/10/21 12:30 | 30/10/21 12:15 | Werder Bremen | FC St. Pauli | 1-1 | 1 - 2 points |
| GER1 | 30/10/21 14:30 | 30/10/21 14:15 | Arminia Bielefeld | FSV Mainz 05 | 1-2 | 1 - 2 points |
| GER1 | 30/10/21 14:30 | 30/10/21 14:15 | SC Freiburg | SpVgg Greuther Fürth | 3-1 | 1 - 2 points |
| GER1 | 30/10/21 14:30 | 30/10/21 14:15 | 1. FC Union Berlin | FC Bayern Munich | 2-5 | 1 - 2 points |
| GER1 | 30/10/21 14:30 | 30/10/21 14:15 | Bayer 04 Leverkusen | VfL Wolfsburg | 0-2 | 1 - 2 points |
| GER1 | 30/10/21 14:30 | 30/10/21 14:15 | Borussia Dortmund | 1. FC Köln | 2-0 | 1 - 2 points |
| GER1 | 30/10/21 17:30 | 30/10/21 17:15 | Eintracht Frankfurt | RB Leipzig | 1-1 | 1 - 2 points |
| GER1 | 31/10/21 14:30 | 31/10/21 14:15 | FC Augsburg | VfB Stuttgart | 4-1 | 1 - 2 points |
| GER1 | 31/10/21 16:30 | 31/10/21 16:15 | Bor. Mönchengladbach | VfL Bochum | 2-1 | 1 - 2 points |