| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 16/10/21 17:30 | 16/10/21 17:30 | UD Levante | FC Getafe | 0-0 | 2 - 4 points |
| 16/10/21 20:00 | 16/10/21 20:00 | Real Sociedad | RCD Mallorca | 1-0 | 2 - 4 points |
| 17/10/21 13:00 | 17/10/21 13:00 | Rayo Vallecano | FC Elche | 2-1 | 2 - 4 points |
| 17/10/21 15:15 | 17/10/21 15:15 | Celta Vigo | FC Sevilla | 0-1 | 2 - 4 points |
| 17/10/21 17:30 | 17/10/21 17:30 | FC Villarreal | CA Osasuna | 1-2 | 2 - 4 points |
| 17/10/21 20:00 | 17/10/21 20:00 | FC Barcelona | FC Valencia | 3-1 | 2 - 4 points |
| 18/10/21 18:00 | 18/10/21 18:00 | Deportivo Alaves | Real Betis Sevilla | 0-1 | 2 - 4 points |
| 18/10/21 20:00 | 18/10/21 20:00 | Espanyol Barcelona | FC Cadiz | 2-0 | 2 - 4 points |
| 01/12/21 20:00 | 01/12/21 20:00 | Real Madrid | Athletic Bilbao | 1-0 | 2 - 4 points |
| 22/12/21 18:00 | 22/12/21 18:00 | FC Granada | Atletico Madrid | 2-1 | 2 - 4 points |