| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 01/10/21 20:00 | 01/10/21 20:00 | Athletic Bilbao | Deportivo Alaves | 1-0 | 2 - 4 points |
| 02/10/21 13:00 | 02/10/21 13:00 | CA Osasuna | Rayo Vallecano | 1-0 | 2 - 4 points |
| 02/10/21 15:15 | 02/10/21 15:15 | RCD Mallorca | UD Levante | 1-0 | 2 - 4 points |
| 02/10/21 17:30 | 02/10/21 17:30 | FC Cadiz | FC Valencia | 0-0 | 2 - 4 points |
| 02/10/21 20:00 | 02/10/21 20:00 | Atletico Madrid | FC Barcelona | 2-0 | 2 - 4 points |
| 03/10/21 13:00 | 03/10/21 13:00 | FC Elche | Celta Vigo | 1-0 | 2 - 4 points |
| 03/10/21 15:15 | 03/10/21 15:15 | Espanyol Barcelona | Real Madrid | 2-1 | 2 - 4 points |
| 03/10/21 17:30 | 03/10/21 17:30 | FC Getafe | Real Sociedad | 1-1 | 2 - 4 points |
| 03/10/21 17:30 | 03/10/21 17:30 | FC Villarreal | Real Betis Sevilla | 2-0 | 2 - 4 points |
| 03/10/21 20:00 | 03/10/21 20:00 | FC Granada | FC Sevilla | 1-0 | 2 - 4 points |