| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 25/09/21 13:00 | 25/09/21 13:00 | Deportivo Alaves | Atletico Madrid | 1-0 | 2 - 4 points |
| 25/09/21 15:15 | 25/09/21 15:15 | FC Valencia | Athletic Bilbao | 1-1 | 2 - 4 points |
| 25/09/21 17:30 | 25/09/21 17:30 | FC Sevilla | Espanyol Barcelona | 2-0 | 2 - 4 points |
| 25/09/21 20:00 | 25/09/21 20:00 | Real Madrid | FC Villarreal | 0-0 | 2 - 4 points |
| 26/09/21 13:00 | 26/09/21 13:00 | RCD Mallorca | CA Osasuna | 2-3 | 2 - 4 points |
| 26/09/21 15:15 | 26/09/21 15:15 | FC Barcelona | UD Levante | 3-0 | 2 - 4 points |
| 26/09/21 17:30 | 26/09/21 17:30 | Real Sociedad | FC Elche | 1-0 | 2 - 4 points |
| 26/09/21 17:30 | 26/09/21 17:30 | Rayo Vallecano | FC Cadiz | 3-1 | 2 - 4 points |
| 26/09/21 20:00 | 26/09/21 20:00 | Real Betis Sevilla | FC Getafe | 2-0 | 2 - 4 points |
| 27/09/21 20:00 | 27/09/21 20:00 | Celta Vigo | FC Granada | 1-0 | 2 - 4 points |