| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 21/09/21 18:30 | 21/09/21 18:30 | FC Getafe | Atletico Madrid | 1-2 | 2 - 4 points |
| 21/09/21 21:00 | 21/09/21 21:00 | Athletic Bilbao | Rayo Vallecano | 1-2 | 2 - 4 points |
| 21/09/21 21:00 | 21/09/21 21:00 | UD Levante | Celta Vigo | 0-2 | 2 - 4 points |
| 22/09/21 18:30 | 22/09/21 18:30 | Espanyol Barcelona | Deportivo Alaves | 1-0 | 2 - 4 points |
| 22/09/21 18:30 | 22/09/21 18:30 | FC Sevilla | FC Valencia | 3-1 | 2 - 4 points |
| 22/09/21 21:00 | 22/09/21 21:00 | Real Madrid | RCD Mallorca | 6-1 | 2 - 4 points |
| 22/09/21 21:00 | 22/09/21 21:00 | FC Villarreal | FC Elche | 4-1 | 2 - 4 points |
| 23/09/21 18:30 | 23/09/21 18:30 | FC Granada | Real Sociedad | 2-3 | 2 - 4 points |
| 23/09/21 18:30 | 23/09/21 18:30 | CA Osasuna | Real Betis Sevilla | 1-3 | 2 - 4 points |
| 23/09/21 21:00 | 23/09/21 21:00 | FC Cadiz | FC Barcelona | 0-0 | 2 - 4 points |