| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 17/09/21 20:00 | 17/09/21 20:00 | Celta Vigo | FC Cadiz | 1-2 | 2 - 4 points |
| 18/09/21 13:00 | 18/09/21 13:00 | Rayo Vallecano | FC Getafe | 3-0 | 2 - 4 points |
| 18/09/21 15:15 | 18/09/21 15:15 | Atletico Madrid | Athletic Bilbao | 0-0 | 2 - 4 points |
| 18/09/21 17:30 | 18/09/21 17:30 | FC Elche | UD Levante | 1-1 | 2 - 4 points |
| 18/09/21 20:00 | 18/09/21 20:00 | Deportivo Alaves | CA Osasuna | 0-2 | 2 - 4 points |
| 19/09/21 13:00 | 19/09/21 13:00 | RCD Mallorca | FC Villarreal | 0-0 | 2 - 4 points |
| 19/09/21 15:15 | 19/09/21 15:15 | Real Sociedad | FC Sevilla | 0-0 | 2 - 4 points |
| 19/09/21 17:30 | 19/09/21 17:30 | Real Betis Sevilla | Espanyol Barcelona | 2-2 | 2 - 4 points |
| 19/09/21 20:00 | 19/09/21 20:00 | FC Valencia | Real Madrid | 1-2 | 2 - 4 points |
| 20/09/21 20:00 | 20/09/21 20:00 | FC Barcelona | FC Granada | 1-1 | 2 - 4 points |