| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/09/21 17:30 | 11/09/21 17:30 | UD Levante | Rayo Vallecano | 1-1 | 2 - 4 points |
| 11/09/21 20:00 | 11/09/21 20:00 | Athletic Bilbao | RCD Mallorca | 2-0 | 2 - 4 points |
| 12/09/21 13:00 | 12/09/21 13:00 | Espanyol Barcelona | Atletico Madrid | 1-2 | 2 - 4 points |
| 12/09/21 15:15 | 12/09/21 15:15 | CA Osasuna | FC Valencia | 1-4 | 2 - 4 points |
| 12/09/21 17:30 | 12/09/21 17:30 | FC Cadiz | Real Sociedad | 0-2 | 2 - 4 points |
| 12/09/21 20:00 | 12/09/21 20:00 | Real Madrid | Celta Vigo | 5-2 | 2 - 4 points |
| 13/09/21 19:00 | 13/09/21 19:00 | FC Getafe | FC Elche | 0-1 | 2 - 4 points |
| 13/09/21 21:00 | 13/09/21 21:00 | FC Granada | Real Betis Sevilla | 1-2 | 2 - 4 points |
| 21/12/21 18:00 | 21/12/21 18:00 | FC Villarreal | Deportivo Alaves | 5-2 | 2 - 4 points |
| 21/12/21 20:30 | 21/12/21 20:30 | FC Sevilla | FC Barcelona | 1-1 | 2 - 4 points |